Mental and Emotional Factors in Women's Health

Only if you receive a product in error and contact Wisp within 15 days of receipt will the company investigate the situation and issue a replacement product if deemed appropriate.

To learn more about Wisp and the platform’s telehealth visit process, check out our full Wisp review. Best prescription pill and runner-up OTC pill Oral tadalafil (generic Cialis) for women is a fairly specialized offering Libido Lift Rx should work in around 30 minutes and last 24-36 hours Prescription “pills” are actually mint-flavored tablets that dissolve under the tongue Drive For Her supplement ingredients have some supportive research Drive For Her subscriptions take 15% off 10% off prescription treatments using code INNERBODY10 Both are unsafe for those who are pregnant or breastfeeding Supplement may contain traces of all nine major allergens Supplements likely require extended use, contrary to product page information More research needed on both tadalafil and oxytocin for FSD “For Her” meds can’t ship to Alabama, California, South Carolina, Guam, or Puerto Rico Hello Cake (often stylized as just “Cake”) is a telehealth company focused on sexual health.

Warnings & Precautions

Only if you receive a product in error and contact Wisp within 15 days of receipt will the company investigate the situation and issue a replacement product if deemed appropriate. To learn more about Wisp and the platform’s telehealth visit process, check out our full Wisp review. Best prescription pill and runner-up OTC pill Oral tadalafil (generic Cialis) for women is a fairly specialized offering Libido Lift Rx should work in around 30 minutes and last 24-36 hours Prescription “pills” are actually mint-flavored tablets that dissolve under the tongue Drive For Her supplement ingredients have some supportive research Drive For Her subscriptions take 15% off 10% off prescription treatments using code INNERBODY10 Both are unsafe for those who are pregnant or breastfeeding Supplement may contain traces of all nine major allergens Supplements likely require extended use, contrary to product page information More research needed on both tadalafil and oxytocin for FSD “For Her” meds can’t ship to Alabama, California, South Carolina, Guam, or Puerto Rico Hello Cake (often stylized as just “Cake”) is a telehealth company focused on sexual health. While the brand offers a wide range of products intended to improve your sexual well-being, we chose its Cake Meds Libido Lift Rx and Hello Cake Drive For Her as our picks for the best prescription pill and runner-up OTC pill. Libido Lift Rx is unique in that it’s the first fast-acting libido-support prescription pill for women that we’ve come across, as of this writing.

Non-GMO, Gluten Free Supplement

Most other options on the market are supplements or either prescription or non-prescription topicals. So, as mentioned previously, this dissolvable tablet may be the closest thing to an “instant” female arousal pill, since it should start working in around 30 minutes. If you’re suffering from a form of female sexual dysfunction, like hypoactive sexual desire disorder (HSDD), Libido Lift Rx will not get to the root of the problem. According to experts, HSDD appears to be caused by an imbalance of certain neurotransmitters and hormones in the brain, which the ingredients in Libido Lift Rx won’t affect.18 Pivoting to the supplement, Hello Cake Drive For Her (previously called “Sex Drive For Her”) is a blend of various herbal ingredients and L-arginine intended to increase sexual desire. While there is some supportive research behind most of this supplement’s ingredients, the evidence isn’t quite as strong as it is for VitaFLUX’s nitric-oxide-boosting amino acids. While the brand offers a wide range of products intended to improve your sexual well-being, we chose its Cake Meds Libido Lift Rx and Hello Cake Drive For Her as our picks for the best prescription pill and runner-up OTC pill.

Libido Lift Rx is unique in that it’s the first fast-acting libido-support prescription pill for women that we’ve come across, as of this writing.

i have little to no sexual desire

In a 2018 study, male Wistar rats were either given one of two reishi extracts (150mg/kg and 300mg/kg) or one of two placebos (sildenafil and distilled water) to evaluate the mushroom’s aphrodisiac potential. Results showed that the lower dose of 150mg/kg was more effective, but, in general, the reishi extract increased the rats’ interest in females and led to increased mounting behavior and mating performance.75 A similar male rat study from 2022 found that reishi mushroom polysaccharides may be able to treat diabetes mellitus-induced erectile dysfunction (DMED), in part by enhancing “the mRNA expression of” nitric oxide synthase (the enzyme that turns L-arginine to L-citrulline and nitric oxide).76 77 This ingredient has the least amount of scientific support. In a 2007 overview of guarana’s history and prospects, researchers state that this plant “has been distorted by market forces into an aphrodisiac and energy booster.”78 This is supported by the findings of a few small studies. A 2009 study gave breast cancer patients 75mg daily for 28 days and found that there were no effects on radiation-induced fatigue or depression.79 And an older study that gave 45 elderly volunteers 1g of guarana found no significant sleep quality, cognitive, or sexual improvements.80 While there isn’t much research on caffeine for female sexual health, the results of a 2023 study showed that, compared to a placebo, acute administration of 300mg of caffeine (around six times the amount in this supplement) increased genital arousal in women experiencing sexual dysfunction due to antidepressants.81 There are a few positive studies that suggest saffron supplementation may be beneficial for sexual dysfunction. A 2022 placebo-controlled study on married women suffering from severe sexual dysfunction found that 15mg of saffron twice daily (30mg total) resulted in a 62% score improvement from baseline after six weeks.

Cranberry Vitamin C Extract

Improvements from saffron over placebo were particularly strong in desire, lubrication, and satisfaction.82 A similar 2012 study on saffron for antidepressant-induced sexual dysfunction gave 38 women either 30mg of saffron or placebo daily for four weeks. In the end, the saffron group experienced “significantly more improvement” in arousal, lubrication, and pain, but not in desire, satisfaction, or orgasm.83 A couple of studies suggest Tribulus terrestris extract may be a potentially effective treatment for sexual dysfunction in women. For example, a 2014 study found that 7.5mg daily for four weeks increased desire, arousal, lubrication, satisfaction, and pain.84 However, a 2020 systematic review explains that, while the data appears positive for FSD, “the certainty of the evidence was very low” and more research is needed.85 But a more recent, unrelated 2021 review investigating T. terrestris for the female reproductive system found that the plant’s positive effects are due to its saponin content (a bitter-tasting compound found in many plants).86 And Drive For Her’s T. terrestris content is standardized to 45% saponins, which is promising. Most other options on the market are supplements or either prescription or non-prescription topicals. So, as mentioned previously, this dissolvable tablet may be the closest thing to an “instant” female arousal pill, since it should start working in around 30 minutes. If you’re suffering from a form of female sexual dysfunction, like hypoactive sexual desire disorder (HSDD), Libido Lift Rx will not get to the root of the problem. According to experts, HSDD appears to be caused by an imbalance of certain neurotransmitters and hormones in the brain, which the ingredients in Libido Lift Rx won’t affect.18 Pivoting to the supplement, Hello Cake Drive For Her (previously called “Sex Drive For Her”) is a blend of various herbal ingredients and L-arginine intended to increase sexual desire. While there is some supportive research behind most of this supplement’s ingredients, the evidence isn’t quite as strong as it is for VitaFLUX’s nitric-oxide-boosting amino acids.

Other Alternative FDA Approved drug for HSDD

This ingredient isn’t added for sexual health; rather, it’s included to potentially improve the bioavailability of the other herbal ingredients. The piperine content in black pepper has been found to increase the bioavailability of various substances by 30-200%. However, it’s currently unknown how well it works on all ingredients, and the effect may be inconsistent on some.87 As with most supplements and medications, there are some safety risks to keep in mind. But, if you can’t take a supplement with such a heavy focus on increasing nitric oxide — or if you simply prefer the idea of an herbal supplement and its potential benefits — then Drive For Her is an option worth considering. (As a side note, Drive For Her only requires you to take two capsules daily instead of VitaFLUX’s six.) In addition to Libido Lift Rx and the Drive blue tablets For Her supplement, it’s worth mentioning that Cake also offers a topical arousal product similar to Wisp’s OMG Cream called “O-Cream Rx for Her.” Both creams include the same 1% concentration of sildenafil (the generic form of Viagra). However, Cake’s prescription is more expensive than Wisp’s for fewer applications. But, unlike Wisp, Cake does offer an extra strength option containing 3% sildenafil, though that’s even pricier. At this time, we’d only recommend opting for Cake’s O-Cream Rx for Her if you’ve tried a 1% sildenafil topical, found it wasn’t strong enough for your needs, and would like to try the 3% sildenafil extra strength variety. That said, let’s examine the ingredients in Libido Lift Rx and Drive For Her. Libido Lift Rx has a fairly small list of ingredients, containing only L-citrulline, oxytocin, and tadalafil. Let’s cover how this prescription’s inclusions work. The research on tadalafil for women is pretty sparse, but the results that exist are promising. As noted in a 2017 review on phosphodiesterase type 5 (PDE5) inhibitors for FSD in older women,70 research has mainly focused on tadalafil for women with FSD due to antidepressants or diabetes.71 72 Both studies (using 5-20mg tadalafil) led to positive outcomes — all patients experienced improvement — but were limited by small sample sizes and lack of placebo control. As researchers continue to investigate the effects of PDE5 inhibitors in women, we’ll update this guide accordingly.

Overdose/Missed Dose

As researchers continue to investigate the effects of PDE5 inhibitors in women, we’ll update this guide accordingly. Since L-citrulline gets converted in the body to L-arginine and nitric oxide, supplementing with this amino acid may lead to increased nitric oxide production.10 There really isn’t any research on oral L-citrulline supplementation alone for female sexual dysfunction or libido support, but some research on men found that 1,500mg could help treat mild to moderate erectile dysfunction.20 However, that’s nearly eight times the amount in Libido Lift Rx. But, to be fair, the L-citrulline in this prescription appears to play more of a supporting role than a main one. There’s very little research on oxytocin as a treatment for sexual dysfunction. One small study from 2015 found that long-term (eight weeks) intranasal oxytocin (32UI) self-administered by women 50 minutes before sexual intercourse improved both sexual function and symptoms of depression.68 And a 2023 study in men receiving testosterone treatment for erectile dysfunction found that oxytocin troches (50-100UI) may be a helpful adjunctive treatment, with 56% of patients (14 out of 26) considered responders to the intervention.69 In contrast to the short ingredient list of Libido Lift Rx, Drive For Her contains seven herbal ingredients and one amino acid.

Solaray D-Mannose 1000mg with CranActin Cranberry Extract - D Mannose Cranberry Supplement with Vitamin C - Supports Urinary Tract and Bladder Health - Vegan, 60 Day Guarantee (60 CT) $28.79 Was $35.99

Here’s how their potential benefits for female sexual health break down. A 2015 study evaluated how Libifem affected sex hormones and sexual function in 80 healthy, menstruating women with self-reported low libido. Participants in the treatment group (600mg per day for eight weeks) experienced a “significant increase” in free testosterone and estradiol, as well as sexual arousal and desire versus the placebo group.73 Other, unrelated research on fenugreek extract found similar results. A 2021 study gave best ed treatments 48 healthy, menstruating women either 250mg of fenugreek extract twice a day or a placebo. Those who took the extract had fewer sexual problems and reduced irritability, along with increased estradiol, free testosterone, and total testosterone.74 The evidence on reishi mushrooms for female sexual dysfunction or libido support is pretty slim, with only a couple of animal studies available at this time. Since L-citrulline gets converted in the body to L-arginine and nitric oxide, supplementing with this amino acid may lead to increased nitric oxide production.10 There really isn’t any research on oral L-citrulline supplementation alone for female sexual dysfunction or libido support, but some research on men found that 1,500mg could help treat mild to moderate erectile dysfunction.20 However, that’s nearly eight times the amount in Libido Lift Rx. But, to be fair, the L-citrulline in this prescription appears to play more of a supporting role than a main one.

Addyi is the #1 Prescribed Treatment for HSDD.1

There’s very little research on oxytocin as a treatment for sexual dysfunction. One small study from 2015 found that long-term (eight weeks) intranasal oxytocin (32UI) self-administered by women 50 minutes before sexual intercourse improved both sexual function and symptoms of depression.68 And a 2023 study in men receiving testosterone treatment for erectile dysfunction found that oxytocin troches (50-100UI) may be a helpful adjunctive treatment, with 56% of patients (14 out of 26) considered responders to the intervention.69 In contrast to the short ingredient list of Libido Lift Rx, Drive For Her contains seven herbal ingredients and one amino acid.

Episode Transcript

But, if you can’t take a supplement with such a heavy focus on increasing nitric oxide — or if you simply prefer the idea of an herbal supplement and its potential benefits — then Drive For Her is an option worth considering. (As a side note, Drive For Her only requires you to take two capsules daily instead of VitaFLUX’s six.) In addition to Libido Lift Rx and the Drive blue tablets For Her supplement, it’s worth mentioning that Cake also offers a topical arousal product similar to Wisp’s OMG Cream called “O-Cream Rx for Her.” Both creams include the same 1% concentration of sildenafil (the generic form of Viagra). However, Cake’s prescription is more expensive than Wisp’s for fewer applications. But, unlike Wisp, Cake does offer an extra strength option containing 3% sildenafil, though that’s even pricier. At this time, we’d only recommend opting for Cake’s O-Cream Rx for Her if you’ve tried a 1% sildenafil topical, found it wasn’t strong enough for your needs, and would like to try the 3% sildenafil extra strength variety.

by Carlyle $9.99

That said, let’s examine the ingredients in Libido Lift Rx and Drive For Her. Libido Lift Rx has a fairly small list of ingredients, containing only L-citrulline, oxytocin, and tadalafil. Let’s cover how this prescription’s inclusions work. The research on tadalafil for women is pretty sparse, but the results that exist are promising. As noted in a 2017 review on phosphodiesterase type 5 (PDE5) inhibitors for FSD in older women,70 research has mainly focused on tadalafil for women with FSD due to antidepressants or diabetes.71 72 Both studies (using 5-20mg tadalafil) led to positive outcomes — all patients experienced improvement — but were limited by small sample sizes and lack of placebo control. Here’s how their potential benefits for female sexual health break down. A 2015 study evaluated how Libifem affected sex hormones and sexual function in 80 healthy, menstruating women with self-reported low libido.

• Pink pills often target women’s reproductive health.
• They may include vitamins like D and E for immunity.
• Certain ingredients are chosen for their antioxidant properties.
• Pink pills can support mood stability during hormonal fluctuations.
• They may be used to improve sleep patterns.
• Some brands promote organic, non-GMO ingredients.
• Users may experience improved overall wellbeing.
• Supplements are more effective when combined with stress management.
• Women should monitor their body's reactions to new supplements.
• Regular health check-ups complement supplement use.
• Pink pills are sometimes part of prenatal or postnatal routines.

Participants in the treatment group (600mg per day for eight weeks) experienced a “significant increase” in free testosterone and estradiol, as well as sexual arousal and desire versus the placebo group.73 Other, unrelated research on fenugreek extract found similar results. A 2021 study gave best ed treatments 48 healthy, menstruating women either 250mg of fenugreek extract twice a day or a placebo. Those who took the extract had fewer sexual problems and reduced irritability, along with increased estradiol, free testosterone, and total testosterone.74 The evidence on reishi mushrooms for female sexual dysfunction or libido support is pretty slim, with only a couple of animal studies available at this time. In a 2018 study, male Wistar rats were either given one of two reishi extracts (150mg/kg and 300mg/kg) or one of two placebos (sildenafil and distilled water) to evaluate the mushroom’s aphrodisiac potential. Results showed that the lower dose of 150mg/kg was more effective, but, in general, the reishi extract increased the rats’ interest in females and led to increased mounting behavior and mating performance.75 A similar male rat study from 2022 found that reishi mushroom polysaccharides may be able to treat diabetes mellitus-induced erectile dysfunction (DMED), in part by enhancing “the mRNA expression of” nitric oxide synthase (the enzyme that turns L-arginine to L-citrulline and nitric oxide).76 77 This ingredient has the least amount of scientific support. In a 2007 overview of guarana’s history and prospects, researchers state that this plant “has been distorted by market forces into an aphrodisiac and energy booster.”78 This is supported by the findings of a few small studies.

• Pink pills are sometimes combined with other supplements, like biotin.
• They can help improve hydration and skin elasticity.
• Some formulations include synbiotics for gut health.
• They are part of natural hormone support strategies.
• Pink pills may aid in muscle recovery after workouts.
• Active ingredients vary widely between brands.
• Benefits may take weeks to become noticeable.
• Consistency and patience are key to results.
• Always check for potential interactions with medications.
• Pink pills can be a boost during stressful periods.
• Use as part of a holistic approach to health.

A 2009 study gave breast cancer patients 75mg daily for 28 days and found that there were no effects on radiation-induced fatigue or depression.79 And an older study that gave 45 elderly volunteers 1g of guarana found no significant sleep quality, cognitive, or sexual improvements.80 While there isn’t much research on caffeine for female sexual health, the results of a 2023 study showed that, compared to a placebo, acute administration of 300mg of caffeine (around six times the amount in this supplement) increased genital arousal in women experiencing sexual dysfunction due to antidepressants.81 There are a few positive studies that suggest saffron supplementation may be beneficial for sexual dysfunction.

A 2022 placebo-controlled study on married women suffering from severe sexual dysfunction found that 15mg of saffron twice daily (30mg total) resulted in a 62% score improvement from baseline after six weeks. Improvements from saffron over placebo were particularly strong in desire, lubrication, and satisfaction.82 A similar 2012 study on saffron for antidepressant-induced sexual dysfunction gave 38 women either 30mg of saffron or placebo daily for four weeks. In the end, the saffron group experienced “significantly more improvement” in arousal, lubrication, and pain, but not in desire, satisfaction, or orgasm.83 A couple of studies suggest Tribulus terrestris extract may be a potentially effective treatment for sexual dysfunction in women. For example, a 2014 study found that 7.5mg daily for four weeks increased desire, arousal, lubrication, satisfaction, and pain.84 However, a 2020 systematic review explains that, while the data appears positive for FSD, “the certainty of the evidence was very low” and more research is needed.85 But a more recent, unrelated 2021 review investigating T. terrestris for the female reproductive system found that the plant’s positive effects are due to its saponin content (a bitter-tasting compound found in many plants).86 And Drive For Her’s T. terrestris content is standardized to 45% saponins, which is promising.

• Pink pills are designed to be visually appealing to women.
• They sometimes include flower extracts like hibiscus.
• Pink pills can support mental focus and alertness.
• Some formulations aim to reduce menopausal hot flashes.
• They are often part of natural health approaches.
• Regular use might lead to hormone stabilization.
• Pink pills are sometimes used to enhance overall feminine vitality.
• They are typically taken with meals to improve absorption.
• Supplements should be used as directed for safety.
• The popularity of pink pills is driven by health trends.
• Scientific evidence varies for many pink pill ingredients.

This ingredient isn’t added for sexual health; rather, it’s included to potentially improve the bioavailability of the other herbal ingredients. The piperine content in black pepper has been found to increase the bioavailability of various substances by 30-200%. However, it’s currently unknown how well it works on all ingredients, and the effect may be inconsistent on some.87 As with most supplements and medications, there are some safety risks to keep in mind.