Coadministration with duvelisib increases AUC of a sensitive CYP3A4 substrate which may increase the risk of toxicities of these drugs.
| Brand Name | Manufacturer | Formulation Type | Price Range | Notes |
|---|---|---|---|---|
| Levitra | Bayer | Tablet | Moderate | Widely used |
| Staxyn | Bayer | Orally disintegrating tablet | Similar price | Alternative formulation |
| Generic Vendors | Multiple | Tablet | Lower | Cost-effective option |
Consider reducing the dose of the sensitive CYP3A4 substrate and monitor for signs of toxicities of the coadministered sensitive CYP3A substrate.
Pregnancy & Lactation
dasatinib will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. deferasiroxdeferasirox will decrease the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. deferasirox will decrease the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. degarelixdegarelix and vardenafil both increase QTc interval. degarelix and vardenafil both increase QTc interval.
Mechanism of Action
At the maximum recommended dose, deutetrabenazine does not prolong QT interval to a clinically relevant extent. Certain circumstances may increase risk of torsade de pointes and/or sudden death in association with drugs that prolong the QTc interval (eg, bradycardia, hypokalemia or hypomagnesemia, coadministration with other drugs that prolong QTc interval, presence of congenital QT prolongation). deutetrabenazine and vardenafil both increase QTc interval. dexamethasonedexamethasone will decrease the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. dexamethasone will decrease the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. duvelisib will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. efavirenzefavirenz will decrease the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.efavirenz and vardenafil both increase QTc interval.
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|---|---|---|---|---|
| Cialis Super Active | 20mg | 120 + 16 Pills | 382.15€ 363.95€ | |
| Kamagra Effervescent Tablets | 100 mg | 28 Pills | 90.83€ 86.50€ | |
| Levitra Original | 20mg | 8 Pills | 65.05€ 61.95€ | |
| Cialis Soft Tabs | 20mg | 30 + 4 Pills | 87.43€ 83.27€ | |
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| Cialis Professional | 20mg | 20 Pills | 78.33€ 74.60€ | |
| Kamagra Oral Jelly | 100mg | 110 + 9 Sachets | 334.87€ 318.92€ | |
| Viagra Generic | 150mg | 30 + 2 Pills | 72.32€ 68.88€ | |
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| Viagra Generic | 100mg | 180 + 8 Pills | 199.37€ 189.88€ |
efavirenz will decrease the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
Vardenafil (Generic Levitra®) FAQs
dofetilide increases toxicity of vardenafil by QTc interval. donepezildonepezil and vardenafil both increase QTc interval. dordavipronedordaviprone and vardenafil both increase QTc interval. Increase the frequency of ECG and electrolyte monitoring. dordaviprone and vardenafil both increase QTc interval. elagolixelagolix decreases levels of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
Key Takeaways
Vardenafil dose may need to be reduced if coadministered with moderate or strong CYP3A4 inhibitors chloramphenicolchloramphenicol will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Vardenafil dose may need to be reduced if coadministered with moderate or strong CYP3A4 inhibitors chloramphenicol will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Vardenafil dose may need to be reduced if coadministered with moderate or strong CYP3A4 inhibitors cimetidinecimetidine will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. cimetidine will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. ECG monitoring is recommended, along with drugs that may prolong the QT interval.
RedBox Rx Reviews
clarithromycinclarithromycin will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Limit vardenafil dose to 2.5 mg/24 hr clozapineclozapine and vardenafil both increase QTc interval. clozapine and vardenafil both increase QTc interval. cobicistatcobicistat will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Vardenafil dose may need to be reduced if coadministered with moderate or strong CYP3A4 inhibitors conivaptan will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Consider increasing CYP3A substrate dose if needed.
What happens if I miss a dose?
DHEA, herbalDHEA, herbal will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. DHEA, herbal will increase the level or effect of vardenafil by affecting hepatic/intestinal bayer vardenafil enzyme CYP3A4 metabolism. diltiazemdiltiazem will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Vardenafil dose may need to be reduced if coadministered with moderate or strong CYP3A4 inhibitors diltiazem will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Vardenafil dose may need to be reduced if coadministered with moderate or strong CYP3A4 inhibitors dofetilidedofetilide increases toxicity of vardenafil by QTc interval. elagolix decreases levels of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
6.1 Clinical Studies Experience
Vardenafil dose may need to be reduced if coadministered with moderate or strong CYP3A4 inhibitors cyclosporine will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Vardenafil dose may need to be reduced if coadministered with moderate or strong CYP3A4 inhibitors dabrafenibdabrafenib will decrease the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. dabrafenib will decrease the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. darifenacindarifenacin will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. darifenacin will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
Related Disease Conditions
darunavirdarunavir will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Coadministration may increase PDE-5 inhibitor adverse effects including hypotension, syncope, visual changes, and prolonged erection; do not exceed vardenafil 2.5 mg q72hr. darunavir will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. dasatinibdasatinib will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.dasatinib and vardenafil both increase QTc interval. Adjust vardenafil dose for ED; not to exceed single dose of 2.5 mg in 72 hr Encorafenib both inhibits and induces CYP3A4 at clinically relevant plasma concentrations.
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doxepindoxepin and vardenafil both increase QTc interval. doxepin and vardenafil both increase QTc interval. dronedaronedronedarone will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Vardenafil dose may need to be reduced if coadministered with moderate or strong CYP3A4 inhibitors dronedarone will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Vardenafil dose may need to be reduced if coadministered with moderate or strong CYP3A4 inhibitors duvelisibduvelisib will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Coadministration of encorafenib with sensitive CYP3A4 substrates may result in increased toxicity or decreased efficacy of these agents.
12.2 Pharmacodynamics
Vardenafil dose may need to be reduced if coadministered with moderate or strong CYP3A4 inhibitors cortisonecortisone will decrease the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. cortisone will decrease the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. crizotinibcrizotinib will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Dose reduction may be needed for coadministered drugs that are predominantly metabolized by CYP3A. crizotinib will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
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crofelemercrofelemer increases levels of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Crofelemer has the potential to inhibit CYP3A4 at concentrations expected in the gut; unlikely to inhibit systemically because minimally absorbed. Vardenafil dose may need to be reduced if coadministered with moderate or strong CYP3A4 inhibitors. crofelemer increases levels of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. cyclosporinecyclosporine will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Encorafenib both inhibits and induces CYP3A4 at clinically relevant plasma concentrations. entacaponeentacapone will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
| Contraindication | Reason | Alternative Action |
|---|---|---|
| Use with Nitrates | Severe hypotension risk | Seek alternative ED treatment |
| Severe Liver Impairment | Reduced metabolism, increased risk | Dose adjustment or avoidance |
| Hypotension (<90/60 mm Hg) | Risk of significant blood pressure drop | Monitor blood pressure |
| Concomitant Potent CYP3A4 Inhibitors | Increased Vardenafil levels | Dose reduction |
Vardenafil dose may need to be reduced if coadministered with moderate or strong CYP3A4 inhibitors entacapone will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
- Vardenafil 10 mg should not be used with certain medications.
- Grapefruit or grapefruit juice may have interactions.
- Inform your doctor about all health conditions before use.
- The medication may cause vision changes or sensitivity.
- Do not use vardenafil if you have liver or kidney issues.
- The pill helps achieve and maintain an erection.
- Follow prescribed dosage to avoid complications.
- Not effective as an aphrodisiac without sexual stimulation.
- Avoid using recreational drugs along with vardenafil.
- Regular medical check-ups are recommended during use.
Vardenafil dose may need to be reduced if coadministered with moderate or strong CYP3A4 inhibitors erythromycin baseerythromycin base will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Limit vardenafil dose to 5 mg/24 hr erythromycin base will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Limit vardenafil dose to 5 mg/24 hr erythromycin lactobionateerythromycin lactobionate will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Limit vardenafil dose to 5 mg/24 hr erythromycin stearateerythromycin stearate will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
- Some users may experience mild flickering vision episodes.
- The efficacy of vardenafil varies between individuals.
- The medication is available in various dosage forms.
- Always follow the specific instructions provided.
- Avoid taking vardenafil with high-fat meals to speed absorption.
- Do not take vardenafil if allergic to its ingredients.
- The drug may cause a temporary burning sensation.
- Use caution in patients with a history of priapism.
- Avoid combining vardenafil with certain herbal supplements.
- Consult your doctor about any ongoing health treatments.
Limit vardenafil dose to 5 mg/24 hr erythromycin stearate will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
- Vardenafil 10 mg is one of several ED treatment options.
- It is generally well-tolerated when used properly.
- Take care to follow your healthcare provider’s instructions.
- Possible interactions with antihypertensive drugs exist.
- Do not drive or operate machinery if feeling dizzy.
- Keep a record of any side effects experienced.
- The medication is not a cure for erectile dysfunction.
- Combining vardenafil with other ED drugs is dangerous.
- Take the tablet with a full glass of water.
- Consult your doctor for dose adjustments if needed.
Limit vardenafil dose to 5 mg/24 hr escitalopramescitalopram increases toxicity of vardenafil by QTc interval. escitalopram increases toxicity of vardenafil by QTc interval. eslicarbazepine acetate will decrease the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism.